Balanced translocations 46, XY, t (8;17)(p23;q11) in brothers with azoospermia

Infertility is one of the most significant human health problems reproductive years. The causes infertility are diverse and numerous-including non-genetic genetic factors. A review this case confirmed this. balanced translocation was found in two siblings diagnosed with azoospermia. After being unable to conceive, older brother his wife had vitro fertilization (IVF) failed. At same time, younger IVF. cytogenetic analysis performed both pairs, it shown that cause their brothers. female showed a regular (46, XX) karyotype, whereas male carry reciprocal [46, XY, t(8;17)(p23;q11)]. This support still first basic diagnostic patients azoospermia other problems.